Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11138214 | 0.86 | ALDH1A1 (0.46) | TOP1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL179026 | 0.85 | TOP1 (0.58) | TOP1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL7166437 | 0.84 | KMT2A (0.60) | ALDH1A1RAB9AKDM4EGAAKMT2A | |
| SCHEMBL11050131 | 0.79 | MAPT (0.55) | ALDH1A1RAB9AGAAKMT2AMEN1 | |
| SCHEMBL179011 | 0.78 | TOP1 (0.58) | TOP1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL108296 | 0.77 | RAB9A (0.54) | TOP1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL6912432 | 0.75 | TOP1 (0.51) | TOP1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL21101929 | 0.75 | KMT2A (0.60) | ALDH1A1RAB9AKDM4EGAAKMT2A | |
| SCHEMBL179005 | 0.74 | TOP1 (0.54) | TOP1ALDH1A1RAB9AKDM4EGAA | |
| SCHEMBL179012 | 0.74 | IMPDH2 (0.54) | TOP1ALDH1A1RAB9AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |