Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31468771 | 0.86 | TDP1 (0.46) | MEN1KMT2ATDP1ALDH1A1CYP2D6 | |
| SCHEMBL11265192 | 0.83 | TDP1 (0.41) | MEN1KMT2ATDP1ALDH1A1CYP2D6 | |
| SCHEMBL10756385 | 0.82 | TSHR (0.48) | MEN1KMT2ATDP1ALDH1A1CYP1A2 | |
| SCHEMBL11743682 | 0.81 | KMT2A (0.42) | MEN1KMT2ATDP1ALDH1A1CYP2D6 | |
| SCHEMBL29727839 | 0.77 | TDP1 (0.56) | MEN1KMT2ATDP1ALDH1A1CYP2D6 | |
| SCHEMBL27683829 | 0.77 | TDP1 (0.56) | MEN1KMT2ATDP1ALDH1A1CYP2D6 | |
| SCHEMBL11081942 | 0.77 | HCAR3 (0.45) | TDP1ALDH1A1TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL31145977 | 0.77 | ALDH1A1 (0.46) | MEN1KMT2ATDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL28187025 | 0.77 | GPR35 (0.50) | MEN1KMT2ATDP1ALDH1A1CYP2D6 | |
| SCHEMBL9575258 | 0.76 | CYP1A2 (0.50) | MEN1KMT2ATDP1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054180-A2 | Process for the preparation of imidazoquinazoline derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-23 | — | — | EP | claimed |
| EP-0054180-A2 | Process for the preparation of imidazoquinazoline derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-06-23 | — | — | EP | disclosed |