Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263342 | 0.88 | L3MBTL1 (0.43) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 | |
| SCHEMBL11261308 | 0.86 | L3MBTL1 (0.41) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 | |
| SCHEMBL11261924 | 0.86 | POLB (0.50) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 | |
| SCHEMBL11266630 | 0.83 | ALDH1A1 (0.38) | ALDH1A1RAB9AMLYCDLMNAKDM4E | |
| SCHEMBL11263315 | 0.83 | L3MBTL1 (0.47) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 | |
| SCHEMBL11263310 | 0.82 | L3MBTL1 (0.49) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 | |
| SCHEMBL11261899 | 0.82 | TACR1 (0.32) | SMN1; SMN2ALDH1A1LMNAKDM4E | |
| SCHEMBL11267589 | 0.80 | L3MBTL1 (0.43) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 | |
| SCHEMBL5312679 | 0.78 | NLRP3 (0.59) | L3MBTL1POLBNLRP3SMN1; SMN2PPID | |
| SCHEMBL11273420 | 0.77 | POLB (0.41) | L3MBTL1POLBNLRP3IDH1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | claimed |
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |