Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15516425 | 0.85 | NLRP3 (0.46) | NLRP3POLBGAATSHRLMNA | |
| SCHEMBL9829734 | 0.83 | NLRP3 (0.56) | NLRP3POLBSMN1; SMN2GAAMGAM | |
| SCHEMBL11136294 | 0.82 | NLRP3 (0.59) | NLRP3POLBGAAMGAMSI | |
| SCHEMBL27974053 | 0.80 | POLB (0.53) | NLRP3POLBSMN1; SMN2GAAMGAM | |
| SCHEMBL11261924 | 0.80 | POLB (0.50) | NLRP3POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11263310 | 0.79 | L3MBTL1 (0.49) | NLRP3POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11267589 | 0.79 | L3MBTL1 (0.43) | NLRP3POLBSMN1; SMN2GAALMNA | |
| SCHEMBL11277397 | 0.78 | L3MBTL1 (0.45) | NLRP3POLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1932411 | 0.77 | HPGD (0.47) | NLRP3POLBSMN1; SMN2TSHRLMNA | |
| Hydrochloric Acid SCHEMBL14988832 | 0.77 | LMNA (0.52) | NLRP3POLBSMN1; SMN2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730117-B1 | THIOUREA COMPOSITIONS AND USES THEREOF | UNIV HONG KONG (CN) | 2015-12-02 | — | — | EP | disclosed |
| US-20150267232-A1 | IN VIVO AND IN VITRO CARBENE INSERTION AND NITRENE TRANSFER REACTIONS CATALYZED BY HEME ENZYMES | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2015-09-24 | — | — | US | disclosed |
| US-7501510-B2 | Thiourea compositions and uses thereof | THE UNIVERSITY OF HONG KONG (CN) | 2009-03-10 | — | — | US | disclosed |
| US-7501510-B2 | Thiourea compositions and uses thereof | THE UNIVERSITY OF HONG KONG (CN) | 2009-03-10 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | NLRP3 756/4885POLB 3870/4885SMN1; SMN2 2580/4885 |
| US-20150267232-A1 | IN VIVO AND IN VITRO CARBENE INSERTION AND NITRENE TRANSFER REACTIONS CATALYZED BY HEME ENZYMES | HMBS, HMOX1, HMOX2 | NLRP3 3521/4885POLB 1288/4885SMN1; SMN2 3363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.