Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
| ▸ | EDNRA | P25101 | 1/20 | 0.59 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026728 | 0.87 | LMNA (0.79) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL10521403 | 0.85 | LMNA (0.70) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9684577 | 0.85 | LMNA (0.59) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11713280 | 0.83 | SMN1; SMN2 (0.47) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11873463 | 0.82 | CASP1 (0.46) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL5571971 | 0.82 | KMT2A (0.57) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11278229 | 0.82 | LMNA (0.55) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11200643 | 0.81 | LMNA (0.55) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL11070919 | 0.81 | ALDH1A1 (0.59) | LMNACYP2C9KMT2AALDH1A1KDM4E | |
| SCHEMBL11192689 | 0.80 | KMT2A (0.53) | LMNAKMT2AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4359578-A | Naphthyridine derivatives and salts thereof useful as antibacterial agents | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1982-11-16 | — | — | US | disclosed |
| US-4352803-A | BACTERICIDES | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
| EP-0009425-B1 | NOVEL NAPHTYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1982-01-27 | — | — | EP | disclosed |
| EP-0009425-A1 | Novel naphtyridine derivatives and pharmaceutical compositions containing them | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1980-04-02 | — | — | EP | disclosed |