Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267619 | 0.88 | HTT (0.46) | HTTTHRBGAAALDH1A1MAPT | |
| SCHEMBL11267621 | 0.80 | HTT (0.44) | HTTTHRBGAAALDH1A1MAPT | |
| SCHEMBL11275694 | 0.78 | STK17A (0.33) | ALDH1A1HPGD | |
| SCHEMBL11279678 | 0.75 | AR (0.41) | HTTTHRBGAAALDH1A1 | |
| SCHEMBL11264791 | 0.75 | HTT (0.42) | HTTTHRBGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL11262363 | 0.74 | ALDH1A1 (0.38) | HTTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL11263310 | 0.70 | L3MBTL1 (0.49) | HTTALDH1A1NPC1LMNASMN1; SMN2 | |
| SCHEMBL11264799 | 0.70 | HTT (0.40) | HTTTHRBGAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL11266398 | 0.70 | NR1H2 (0.34) | SMN1; SMN2 | |
| SCHEMBL11276944 | 0.69 | NR1H2 (0.42) | GAAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |