Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175083 | 0.84 | HDAC8 (0.56) | ACEABCB11HDAC8MMP2 | |
| SCHEMBL9175072 | 0.84 | HDAC8 (0.56) | ACEABCB11HDAC8MMP2 | |
| Bromide SCHEMBL7342017 | 0.83 | HDAC8 (0.55) | ACEABCB11HDAC8MMP2 | |
| Bromide SCHEMBL7342024 | 0.83 | HDAC8 (0.55) | ACEABCB11HDAC8MMP2 | |
| SCHEMBL11260996 | 0.81 | ACE (0.53) | ACEABCB11HDAC8MMP2 | |
| SCHEMBL11212483 | 0.81 | ACE (0.53) | ACEABCB11 | |
| SCHEMBL11216045 | 0.80 | ACE (0.53) | ACEABCB11HDAC8MMP2 | |
| SCHEMBL11216048 | 0.80 | ACE (0.53) | ACEABCB11HDAC8MMP2 | |
| SCHEMBL14776984 | 0.78 | MMP2 (0.49) | ACEABCB11HDAC8MMP2 | |
| SCHEMBL11266964 | 0.78 | REN (0.56) | ACEABCB11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4311705-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-19 | — | — | US | disclosed |