Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 14/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CDH1 | P12830 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11282455 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2GPBAR1CDH1CTNNB1TCF7L2 | |
| SCHEMBL11280642 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2CDH1CTNNB1TCF7L2THRB | |
| SCHEMBL11274781 | 0.75 | TRPV1 (0.42) | SMN1; SMN2GPBAR1 | |
| SCHEMBL11285150 | 0.74 | RAB9A (0.64) | SMN1; SMN2THRB | |
| SCHEMBL9550221 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2CDH1CTNNB1TCF7L2THRB | |
| SCHEMBL9550216 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2CDH1CTNNB1TCF7L2THRB | |
| SCHEMBL9195204 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2CDH1CTNNB1TCF7L2THRB | |
| SCHEMBL9550203 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2CDH1CTNNB1TCF7L2THRB | |
| SCHEMBL6027661 | 0.70 | SMN1; SMN2 (0.60) | SMN1; SMN2CYP2C19CDH1CTNNB1TCF7L2 | |
| SCHEMBL9550201 | 0.70 | SMN1; SMN2 (0.50) | SMN1; SMN2CYP2C19CDH1CTNNB1TCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322429-A | Isoxazolylbenzamides as insecticides | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | claimed |
| US-4322429-A | Isoxazolylbenzamides as insecticides | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0048162-A1 | Isoxazolylbenzamides | ELI LILLY AND COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |