Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paramethasone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | PGR | P06401 | 8/20 | 0.79 |
| ▸ | AR | P10275 | 5/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paramethasone Acetate SCHEMBL9270992 | 1.00 | ABCB11 (1.00) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone Acetate SCHEMBL7126 | 1.00 | ABCB11 (1.00) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone Acetate SCHEMBL13423597 | 1.00 | ABCB11 (1.00) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone Acetate SCHEMBL11070642 | 1.00 | ABCB11 (1.00) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone Acetate SCHEMBL13929947 | 1.00 | ABCB11 (1.00) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone Acetate SCHEMBL11443533 | 1.00 | ABCB11 (1.00) | ABCB11PGRARCYP3A4F2 | |
| SCHEMBL13929918 | 0.91 | ABCB11 (0.83) | ABCB11PGRARCYP3A4F2 | |
| SCHEMBL11742957 | 0.90 | ABCB11 (0.81) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone SCHEMBL5579847 | 0.89 | PGR (0.96) | ABCB11PGRARCYP3A4F2 | |
| Paramethasone SCHEMBL11126091 | 0.89 | PGR (1.00) | ABCB11PGRARCYP3A4NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4346037-A | Base catalyzed acylation with enol esters | THE UPJOHN COMPANY (US) | 1982-08-24 | — | — | US | claimed |
| US-4346037-A | Base catalyzed acylation with enol esters | THE UPJOHN COMPANY (US) | 1982-08-24 | — | — | US | disclosed |