Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 9/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL11275546 | 0.93 | BCHE (0.53) | BCHEGAAMAPTSLC2A1MEN1 | |
| SCHEMBL4672887 | 0.85 | BCHE (0.51) | BCHEDRD4DRD2ADRA1DADRA1A | |
| SCHEMBL22495340 | 0.85 | GAA (0.63) | BCHEGAAMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11270300 | 0.85 | GAA (0.59) | BCHEGAAMAPTSLC2A1MPO | |
| SCHEMBL9328648 | 0.82 | GAA (0.63) | BCHEGAAMAPTDRD4MPO | |
| SCHEMBL580289 | 0.82 | BCHE (0.77) | BCHEGAAMAPTSLC2A1DRD4 | |
| SCHEMBL3695539 | 0.82 | BCHE (0.77) | BCHEGAAMAPTSLC2A1DRD4 | |
| Hydrochloric Acid SCHEMBL9332806 | 0.80 | GAA (0.78) | BCHEGAAMAPTSLC2A1DRD4 | |
| Bromide SCHEMBL11279741 | 0.80 | L3MBTL1 (0.51) | MAPTDRD4DRD2DRD3KMT2A | |
| Bromide SCHEMBL11269859 | 0.80 | SIGMAR1 (0.42) | MAPTDRD4DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4327022-A | Heterocyclic alkyl naphthols | STERLING DRUG INC. (US) | 1982-04-27 | — | — | US | disclosed |
| US-4169108-A | 5(OR 6)-[(Substituted-amino)alkyl]-2,3-naphthalenediols | STERLING DRUG INC. (US) | 1979-09-25 | — | — | US | disclosed |