Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 2/20 | 0.57 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 6/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18114812 | 0.89 | OPRK1 (0.62) | DRD2ADRA1ADRD3SLC6A5OPRK1 | |
| SCHEMBL11877395 | 0.87 | GAA (0.76) | GAAMAPTMPOMEN1KMT2A | |
| SCHEMBL6539985 | 0.86 | GAA (0.51) | GAAMAPTDRD2DRD4ADRA1D | |
| SCHEMBL6539919 | 0.84 | HTR6 (0.51) | GAAMAPTDRD2DRD4ADRA1D | |
| SCHEMBL2538044 | 0.83 | CYP1A2 (0.62) | SLC2A4SLC6A5TAAR1 | |
| SCHEMBL5177175 | 0.83 | CA1 (0.52) | GAADRD2DRD4ADRA1DADRA1A | |
| SCHEMBL6254596 | 0.83 | SLC2A4 (0.65) | MAPTDRD2DRD4ADRA1DADRA1A | |
| Bromide SCHEMBL11280236 | 0.82 | BCHE (0.59) | GAAMAPTDRD2DRD4ADRA1D | |
| SCHEMBL580289 | 0.81 | BCHE (0.77) | GAAMAPTDRD4MPOMEN1 | |
| SCHEMBL3695539 | 0.81 | BCHE (0.77) | GAAMAPTDRD4MPOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0356989-B1 | Sulfon amides with a tetrazolyl rest, process for their preparation an therapeutic agents | BOEHRINGER MANNHEIM GMBH (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-5173500-A | Inhibiting thrombocyte aggregation | BOEHRINGER MANNHEIM GMBH (DE) | 1992-12-22 | — | — | US | disclosed |
| US-5037990-A | Antagonist, antagonism, bronchodilator; antiischemic agents, treatment of cardiovascular disorder, kidney dialysis; and antiulcer agent | BOEHRINGER MANNHEIM GMBH (DE) | 1991-08-06 | — | — | US | disclosed |
| CN-1045780-A | The preparation of new sulfonamide derivatives | BOEHRINGER MANNHEIM GMBH (DE) | 1990-10-03 | — | — | CN | disclosed |
| EP-0356989-A2 | Sulfon amides with a tetrazolyl rest, process for their preparation an therapeutic agents | Roche Diagnostics GmbH (DE) | 1990-03-07 | — | — | EP | disclosed |