SCHEMBL1128052

SCHEMBL1128052

O=CC(Br)c1ccc(F)cc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 4/20 0.43
CES1 P23141 4/20 0.43
IDO1 P14902 1/20 0.38
TDO2 P48775 1/20 0.38
ALDH1A1 P00352 2/20 0.35
ATM Q13315 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
NFE2L2 Q16236 3/20 0.33
CA3 P07451 1/20 0.31
CA6 P23280 1/20 0.31
CA5A P35218 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
CA5B Q9Y2D0 1/20 0.31
MC4R P32245 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20551270 0.84 CES2 (0.43) CES2CES1ALDH1A1NFE2L2CA3
SCHEMBL6442608 0.84 CES2 (0.43) CES2CES1ALDH1A1NFE2L2CA3
SCHEMBL3398239 0.82 APLNR (0.42) ALDH1A1
SCHEMBL2234260 0.82 PKM (0.34) CES2CES1
SCHEMBL1701612 0.81 CA3 (0.42) CES2CES1CA3CA6CA5A
SCHEMBL20551400 0.81 MDM2 (0.38) TDP1CYP3A4
SCHEMBL1554814 0.81 MIF (0.39) CES2CES1ALDH1A1TDP1
SCHEMBL20551407 0.81 MDM2 (0.39) ALDH1A1
SCHEMBL2932458 0.81 MDM2 (0.39) ALDH1A1
SCHEMBL2489407 0.81 HDAC4 (0.33) CES2CES1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3619209-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS Glenmark Pharmaceuticals S.A. (CH) 2020-03-11 EP disclosed
EP-3519391-A1 NOVEL 5-SUBSTITUTED IMIDAZOLYLMETHYL DERIVATIVES Bayer CropScience Aktiengesellschaft (DE) 2019-08-07 EP disclosed
WO-2018203298-A1 SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2018-11-08 WO disclosed
WO-2018060074-A1 NOVEL 5-SUBSTITUTED IMIDAZOLYLMETHYL DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-04-05 WO disclosed
WO-2016201168-A1 OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF FORUM PHARMCEUTICALS INC. (US) 2016-12-15 WO disclosed
EP-2970282-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS Incyte Corporation (US) 2016-01-20 EP disclosed
WO-2015088565-A1 P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2015-06-18 WO disclosed
WO-2014143768-A1 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS INCYTE CORPORATION (US) 2014-09-18 WO disclosed
WO-2014013076-A1 HEXAHYDROPYRROLOTHIAZINE COMPOUNDS EISAI R&D MANAGEMENT CO., LTD. (JP) 2014-01-23 WO disclosed
EP-2376489-A1 Alkaloid aminoester derivatives and medicinal composition thereof Chiesi Farmaceutici S.p.A. (IT) 2011-10-19 EP disclosed
WO-2007140439-A2 COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF ABBOTT LABORATORIES (US) 2007-12-06 WO disclosed
WO-2007096764-A2 BICYCLIC HETEROARYL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS GLENMARK PHARMACEUTICALS S.A. (US) 2007-08-30 WO disclosed
WO-2007028051-A2 NOVEL IMIDAZO BASED HETEROCYCLES ABBOTT LABORATORIES (US) 2007-03-08 WO disclosed
WO-2006123145-A1 ANTIFUNGAL AGENTS F2G LTD (GB) 2006-11-23 WO disclosed
EP-1583742-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-12 EP disclosed
EP-1487794-A1 MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS Bayer Aktiengesellschaft (DE) 2004-12-22 EP disclosed
WO-2004060870-A1 NOVEL CB 1 RECEPTOUR INVERSE AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2004-07-22 WO disclosed
WO-2003076405-A1 MONOCYCLIC AROYLPYRIDINONES AS ANTIINFLAMMATORY AGENTS BAYER HEALTHCARE AG (DE) 2003-09-18 WO disclosed
EP-0819124-A1 AZOLE COMPOUNDS WITH ANTIMYCOTIC ACTIVITY FOR HUMAN AND VETERINARY USE ZAMBON GROUP S.p.A. (IT) 1998-01-21 EP disclosed
WO-1996031490-A1 AZOLE COMPOUNDS WITH ANTIMYCOTIC ACTIVITY FOR HUMAN AND VETERINARY USE ZAMBON GROUP S.P.A. (IT) 1996-10-10 WO disclosed