Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 7/20 | 0.34 |
| ▸ | ELANE | P08246 | 11/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL11287916 | 0.90 | ELANE (0.35) | ELANE | |
| Alcohol SCHEMBL11286254 | 0.88 | NFKB1 (0.30) | — | |
| Alcohol SCHEMBL11277420 | 0.88 | ALOX15 (0.38) | LMNACYP3A4HIF1AADRB2 | |
| Alcohol SCHEMBL11281555 | 0.86 | ALDH1A1 (0.36) | ALDH1A1LMNACYP3A4HIF1AADRB2 | |
| Alcohol SCHEMBL11283473 | 0.86 | KMT2A (0.36) | ALDH1A1CYP3A4ADRB2 | |
| Alcohol SCHEMBL11282266 | 0.85 | ESR1 (0.38) | ALDH1A1LMNA | |
| Alcohol SCHEMBL11277403 | 0.83 | KMT2A (0.43) | LMNACYP3A4ADRB2CA2 | |
| Alcohol SCHEMBL11283773 | 0.76 | ALOX15 (0.47) | ALDH1A1LMNACYP3A4HIF1ACA2 | |
| Alcohol SCHEMBL11282468 | 0.76 | THRB (0.34) | ALDH1A1LMNACYP3A4HIF1AADRB2 | |
| Alcohol SCHEMBL11288385 | 0.76 | ALOX15 (0.47) | ALDH1A1LMNACYP3A4HIF1ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336400-A | BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS | STERLING DRUG INC. (US) | 1982-06-22 | — | — | US | claimed |
| US-4336400-A | BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS | STERLING DRUG INC. (US) | 1982-06-22 | — | — | US | disclosed |
| US-RE30241-E | BRONCHODILATION, ADRENERGIC STIMULANTS | STERLING DRUG INC. (US) | 1980-03-25 | — | — | US | disclosed |
| US-4138581-A | BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS | STERLING DRUGS INC. (US) | 1979-02-06 | — | — | US | disclosed |