Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | HBB | P68871 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11286481 | 0.87 | SRC (0.35) | TLR8TLR7SREBF2GPR84KDM4E | |
| SCHEMBL28520283 | 0.74 | TAAR1 (0.40) | CYP3A4 | |
| SCHEMBL29987813 | 0.74 | CYP19A1 (0.47) | ALDH1A1ATMMAPK1TDP1CYP3A4 | |
| SCHEMBL3804549 | 0.73 | NOS2 (0.36) | KDM4EALDH1A1HPGDGAAHTT | |
| SCHEMBL840292 | 0.69 | NOS2 (0.33) | KDM4EALDH1A1HSD17B10NOS2CASP7 | |
| SCHEMBL3802566 | 0.69 | HTT (0.39) | KDM4EALDH1A1MAPTHTTNOS2 | |
| SCHEMBL4576433 | 0.68 | PRKCI (0.44) | TLR8TLR7SREBF2KDM4EALDH1A1 | |
| SCHEMBL11700431 | 0.68 | NOS2 (0.39) | KDM4EALDH1A1HPGDGAANOS2 | |
| SCHEMBL3801329 | 0.68 | KDM4E (0.39) | KDM4EALDH1A1HTTNOS2POLB | |
| SCHEMBL23050191 | 0.67 | GAA (0.38) | TLR8TLR7SREBF2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055043-A2 | 6,7,8,9-Tetrahydro-3H-benz(e)indolamine derivatives, processes for their preparation and intermediates used therein, and pharmaceutical compositions containing the indolamine derivatives | AYERST, MCKENNA AND HARRISON INC. (CA) | 1982-06-30 | — | — | EP | disclosed |