Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266474 | 0.97 | DRD3 (0.56) | HTR1ADRD2HTR7HTR2AADRA1A | |
| SCHEMBL11276677 | 0.90 | KCNH2 (0.61) | HTR1ADRD2HTR7HTR2ADRD3 | |
| SCHEMBL11273977 | 0.88 | HTR1A (0.56) | HTR1ADRD2HTR7HTR2ADRD3 | |
| SCHEMBL11279326 | 0.88 | HTR1A (0.63) | HTR1ADRD2HTR2AADRA1ADRD3 | |
| SCHEMBL11273950 | 0.87 | HRH3 (0.48) | HTR1ADRD2HTR2ADRD3HRH3 | |
| SCHEMBL11273095 | 0.87 | DRD2 (0.58) | HTR1ADRD2HTR2ADRD3HRH3 | |
| SCHEMBL11808547 | 0.85 | DRD3 (0.53) | HTR1ADRD2HTR7HTR2AADRA1A | |
| SCHEMBL11809668 | 0.85 | HTR1A (0.63) | HTR1ADRD2HTR2AADRA1ADRD3 | |
| SCHEMBL11266147 | 0.84 | SLC6A2 (0.55) | HTR1ADRD2HTR7HTR2ADRD3 | |
| SCHEMBL11813710 | 0.84 | HTR1A (0.51) | HTR1ADRD2HTR2ADRD3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |