Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.58 |
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | DRD3 | P35462 | 5/20 | 0.58 |
| ▸ | HTR2A | P28223 | 5/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.58 |
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
| ▸ | DRD5 | P21918 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11811688 | 0.98 | DRD2 (0.58) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11270602 | 0.97 | HTR1A (0.54) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11273977 | 0.90 | HTR1A (0.56) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11279326 | 0.90 | HTR1A (0.63) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11276199 | 0.89 | KCNH2 (0.58) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11809668 | 0.87 | HTR1A (0.63) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11282809 | 0.87 | HTR1A (0.55) | DRD2HTR1ADRD3HTR2ADRD4 | |
| SCHEMBL11266147 | 0.86 | SLC6A2 (0.55) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11813710 | 0.86 | HTR1A (0.51) | DRD2HTR1ADRD3HTR2ASIGMAR1 | |
| SCHEMBL11270870 | 0.86 | HTR1A (0.59) | DRD2HTR1ADRD3HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |