Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.45 |
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275047 | 0.87 | NCF1 (0.58) | NCF1KDM4EMAPTALDH1A1GLA | |
| SCHEMBL4770137 | 0.76 | SMN1; SMN2 (0.51) | MAPTALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL29124131 | 0.74 | NCF1 (0.50) | NCF1KDM4EMAPTALDH1A1GLA | |
| SCHEMBL177816 | 0.74 | HTR3A (0.61) | NCF1KDM4EALDH1A1LMNA | |
| SCHEMBL4262506 | 0.73 | NCF1 (0.56) | NCF1KDM4EMAPTALDH1A1GLA | |
| SCHEMBL30744833 | 0.72 | KDM4E (0.55) | KDM4EMAPTALDH1A1GLAGAA | |
| SCHEMBL11791112 | 0.71 | KDM4E (0.56) | NCF1KDM4EMAPTALDH1A1GLA | |
| SCHEMBL12215244 | 0.71 | HTR2C (0.59) | NCF1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL27927276 | 0.69 | KDM4E (0.51) | NCF1KDM4EMAPTALDH1A1GLA | |
| SCHEMBL30389776 | 0.69 | PIK3CD (0.59) | KDM4EMAPTALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4324894-A | NARCOSIS POTENTIATING | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 1982-04-13 | — | — | US | disclosed |