Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11284523 | 0.91 | KDM4E (0.50) | EGFRNPC1RAB9APARP1KMT2A | |
| SCHEMBL11280137 | 0.88 | EGFR (0.56) | EGFRNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11292150 | 0.86 | KDM4E (0.50) | EGFRNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11983218 | 0.86 | SERPINE1 (0.51) | EGFRNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11291470 | 0.86 | ADORA3 (0.55) | EGFRNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11282857 | 0.85 | ROCK2 (0.47) | EGFRNPC1RAB9APARP1KMT2A | |
| SCHEMBL11983219 | 0.85 | KDM4E (0.60) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL11983190 | 0.85 | CFTR (0.53) | EGFRNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11983214 | 0.83 | L3MBTL1 (0.57) | EGFRNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11280875 | 0.81 | SERPINE1 (0.48) | EGFRNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059698-A1 | Heterocyclic carboxamides, compositions containing such compounds, processes for their preparation and methods of treatment therewith | AB LEO (SE) | 1982-09-08 | — | — | EP | disclosed |