Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11293586 | 0.86 | PDE3B (0.51) | PDE3BPDE3AP2RY12GPBAR1CYSLTR1 | |
| SCHEMBL11271989 | 0.84 | PDE3B (0.42) | PDE3BPDE3AP2RY12POLBPKM | |
| SCHEMBL11272074 | 0.81 | PDE3B (0.54) | PDE3BPDE3AP2RY12POLBPKM | |
| SCHEMBL11273567 | 0.80 | KMT2A (0.45) | GPBAR1CYSLTR1CYSLTR2POLBMEN1 | |
| SCHEMBL11273270 | 0.78 | CYSLTR1 (0.39) | PDE3BPDE3AGPBAR1CYSLTR1CYSLTR2 | |
| Quinoline SCHEMBL11273570 | 0.77 | MCL1 (0.46) | PDE3BPDE3AGPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL10835192 | 0.76 | MAOB (0.44) | PDE3BPDE3AP2RY12GPBAR1CYSLTR1 | |
| SCHEMBL11277093 | 0.74 | MAOA (0.55) | PDE3BPDE3AP2RY12DRD2CYP1A2 | |
| SCHEMBL11272206 | 0.72 | LMNA (0.48) | PDE3BPDE3ACYP1A2CYP2C19TNKS2 | |
| SCHEMBL9002571 | 0.72 | PDE3B (0.48) | PDE3BPDE3AP2RY12POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |