Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 19/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 18/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288900 | 0.86 | SIGMAR1 (0.57) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11289969 | 0.82 | HTR2A (0.49) | OPRM1ADRA2A | |
| SCHEMBL11284729 | 0.81 | SIGMAR1 (0.51) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11229494 | 0.78 | DRD2 (0.42) | OPRM1LMNAADRA2ACYP2D6TSHR | |
| SCHEMBL11286315 | 0.75 | SIGMAR1 (0.66) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11286148 | 0.75 | SIGMAR1 (0.57) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11288157 | 0.74 | HTR1A (0.53) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11288975 | 0.73 | SIGMAR1 (0.53) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11281329 | 0.72 | SIGMAR1 (0.48) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11219416 | 0.70 | NEK2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |