Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.44 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558285 | 0.81 | KDM4E (0.39) | SLC6A2SLC6A4HTR2AHTR2BSLC6A3 | |
| SCHEMBL8588169 | 0.80 | HTR2C (0.46) | SLC6A2SLC6A4HTR2AHTR2BHTR2C | |
| SCHEMBL5915126 | 0.77 | DRD2 (0.51) | HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL6446140 | 0.76 | HTR2C (0.50) | HTR2AHTR2BHTR2CCYP3A4TAAR1 | |
| SCHEMBL410563 | 0.75 | P2RX7 (0.43) | SLC6A2SLC6A4HTR2AHTR2BSLC6A3 | |
| SCHEMBL470870 | 0.75 | P2RX7 (0.43) | SLC6A2SLC6A4HTR2AHTR2BSLC6A3 | |
| SCHEMBL15210114 | 0.74 | PKM (0.40) | HTR2AHTR2BHTR2CTAAR1ALDH1A1 | |
| SCHEMBL1074633 | 0.73 | HTR2C (0.47) | HTR2AHTR2BHTR1AHTR2C | |
| SCHEMBL11874335 | 0.72 | SLC6A2 (0.38) | SLC6A2SLC6A4HTR2AHTR2BSLC6A3 | |
| SCHEMBL18950390 | 0.72 | HTR2C (0.46) | HTR2AHTR2BHTR2CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067769-A1 | 1,2,3,4,4a,9b-Hexahydro-4a-piperazinylmethyl-4-dibenzofuranones or substituted 4-dibenzofuranoles, process for their preparation and their therapeutic use | RIOM LABORATOIRES- C.E.R.M. (Société Anonyme) (FR) | 1982-12-22 | — | — | EP | disclosed |