Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470870 | 1.00 | P2RX7 (0.43) | P2RX7PRCPSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL404339 | 0.87 | TAAR1 (0.44) | SLC6A2SLC6A4SLC6A3CYP2D6TAAR1 | |
| SCHEMBL18741430 | 0.85 | ADRB1 (0.40) | TAAR1HTR2AHTR2CHTR2B | |
| SCHEMBL30853839 | 0.84 | HTR3A (0.44) | P2RX7SLC6A3HTR2AHTR2CHTR2B | |
| SCHEMBL3978422 | 0.83 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CYP2D6TAAR1 | |
| SCHEMBL27843488 | 0.83 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3CYP2D6TAAR1 | |
| SCHEMBL22382688 | 0.83 | RIPK1 (0.43) | SLC6A2SLC6A4RIPK1HTR2AHTR2C | |
| SCHEMBL27506411 | 0.83 | TAAR1 (0.44) | SLC6A2SLC6A4SLC6A3CYP2D6TAAR1 | |
| SCHEMBL470874 | 0.82 | CHRNB2 (0.47) | TDP1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL1579802 | 0.82 | SIGMAR1 (0.50) | SLC6A2SLC6A4SLC6A3CYP2D6CALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048405-A | Aryl-substituted piperazine derivatives | NEUROGEN CORP (US) | 2007-10-03 | — | — | CN | claimed |
| CN-117402124-A | Aryl sulfonamide compound and anti-influenza application thereof | 中国医学科学院医药生物技术研究所 | 2024-01-16 | — | — | CN | disclosed |
| US-20210332046-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2021-10-28 | — | — | US | disclosed |
| US-11155551-B2 | Nicotinic acetylcholine receptor silent agonists | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2021-10-26 | — | — | US | disclosed |
| US-20200247804-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2020-08-06 | — | — | US | disclosed |
| US-10662191-B2 | Nicotinic acetylcholine receptor silent agonists | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-20180298002-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2018-10-18 | — | — | US | disclosed |
| US-9796723-B2 | Method of treatment using substituted imidazo[1,2b]pyridazine compounds | ARRAY BIOPHARMA, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170114068-A1 | Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds | ARRAY BIOPHARMA, INC. | 2017-04-27 | — | — | US | disclosed |
| WO-2017066558-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| WO-2006005195-A1 | NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | UNIVERSITé LAVAL (CA) | 2006-01-19 | — | — | WO | disclosed |
| CN-1703401-A | Substituted 1-benzyl-4-arylpiperazine analogs as ligands for melanin concentrating hormone receptors | NEUROGEN CORP (US) | 2005-11-30 | — | — | CN | disclosed |
| US-6953801-B2 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | NEUROGEN CORPORATION (US) | 2005-10-11 | — | — | US | disclosed |
| US-20050182068-A1 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | HUTCHISON ALAN (US) | 2005-08-18 | — | — | US | disclosed |
| US-20050065162-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION | 2005-03-24 | — | — | US | disclosed |
| EP-1389189-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2004-02-18 | — | — | EP | disclosed |
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002094799-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | NEUROGEN CORPORATION (US) | 2002-11-28 | — | — | WO | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |
| EP-0211746-A1 | Phenyl-piperazine derivatives, process for their preparation and therapeutical use | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1987-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180298002-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | CHRNA7, CHRNA2, CHRNE | P2RX7 28/4885PRCP 2006/4885SLC6A2 801/4885 |
| US-20170114068-A1 | Method of Treatment Using Substituted Imidazo[1,2b]Pyridazine Compounds | COL2A1, COL1A1, IFNAR1 | P2RX7 4/4885PRCP 935/4885SLC6A2 3497/4885 |
| US-11155551-B2 | Nicotinic acetylcholine receptor silent agonists | CHRNA7, CHRNA2, CHRNE | P2RX7 28/4885PRCP 2006/4885SLC6A2 801/4885 |
| US-10662191-B2 | Nicotinic acetylcholine receptor silent agonists | CHRNA7, CHRNA2, CHRNE | P2RX7 28/4885PRCP 2006/4885SLC6A2 801/4885 |
| US-20050065162-A1 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED 1-BENZYL-4-ARYL PIPERAZINE ANALOGUES | MCHR1, MCHR2, MC1R | P2RX7 1613/4885PRCP 299/4885SLC6A2 562/4885 |
| US-20200247804-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | CHRNA7, CHRNA2, CHRNE | P2RX7 28/4885PRCP 2006/4885SLC6A2 801/4885 |
| US-20210332046-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS | CHRNA7, CHRNA2, CHRNE | P2RX7 28/4885PRCP 2006/4885SLC6A2 801/4885 |
| US-20050182068-A1 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues | MCHR1, MCHR2, MC1R | P2RX7 1613/4885PRCP 299/4885SLC6A2 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.