Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPP1R15A | O75807 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.46 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3302004 | 0.79 | PPP1R15A (0.48) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL29010084 | 0.77 | PPP1R15A (0.47) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL9127344 | 0.75 | PPP1R15A (0.46) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL30587141 | 0.75 | ALDH1A1 (0.65) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL30011286 | 0.75 | ALDH1A1 (0.54) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL16951940 | 0.75 | L3MBTL1 (0.50) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL1547373 | 0.75 | L3MBTL1 (0.46) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL95211 | 0.75 | ALDH1A1 (0.54) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL40188 | 0.75 | ALDH1A1 (0.65) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 | |
| SCHEMBL16956463 | 0.73 | L3MBTL1 (0.44) | PPP1R15AMELKPPP1R15BNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801509-B | The preparation method and purposes of a kind of chalcone derivative | 中国科学院新疆理化技术研究所 | 2018-01-05 | — | — | CN | disclosed |
| CN-105801509-A | Preparation method and application of phenylisoxazole-containing chalcone derivatives | 中国科学院新疆理化技术研究所 | 2016-07-27 | — | — | CN | disclosed |
| EP-2283007-A2 | PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF | Sanofi-aventis (FR) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141532-A2 | PYRROLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2009-11-26 | — | — | WO | disclosed |