Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129303 | 0.81 | EIF4A3 (0.34) | LMNATRPV1NPC1RAB9A | |
| SCHEMBL4561883 | 0.81 | NPC1 (0.36) | NPC1RAB9A | |
| SCHEMBL6031580 | 0.79 | PDE4A (0.40) | LMNATRPV1 | |
| SCHEMBL1128497 | 0.72 | NPC1 (0.45) | LMNATRPV1NPC1RAB9A | |
| SCHEMBL1128920 | 0.70 | NPC1 (0.46) | LMNATRPV1NPC1RAB9A | |
| SCHEMBL1129053 | 0.69 | NPC1 (0.45) | LMNANPC1RAB9A | |
| SCHEMBL12052973 | 0.68 | ADORA3 (0.42) | LMNATRPV1 | |
| SCHEMBL1128996 | 0.68 | NPC1 (0.44) | LMNANPC1RAB9A | |
| SCHEMBL22761577 | 0.67 | ADORA3 (0.38) | LMNA | |
| SCHEMBL24332933 | 0.67 | CRHR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |