Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129035 | 0.81 | HTT (0.35) | NPC1RAB9AHTTLMNA | |
| SCHEMBL20919865 | 0.77 | EGLN1 (0.41) | NPC1RAB9ASSTR5HTT | |
| SCHEMBL7886419 | 0.74 | EGLN1 (0.44) | NPC1RAB9AHTT | |
| SCHEMBL1128996 | 0.73 | NPC1 (0.44) | NPC1RAB9AEIF4A3GCGRLMNA | |
| SCHEMBL1128920 | 0.72 | NPC1 (0.46) | NPC1RAB9ALMNA | |
| SCHEMBL14445627 | 0.69 | EIF4A3 (0.30) | EIF4A3 | |
| SCHEMBL12110225 | 0.69 | ACLY (0.35) | HTTLMNA | |
| SCHEMBL16364071 | 0.68 | KDM4E (0.40) | — | |
| SCHEMBL1128497 | 0.68 | NPC1 (0.45) | NPC1RAB9ALMNA | |
| SCHEMBL26203728 | 0.67 | GABRA1 (0.41) | EIF4A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282762-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | Intermune, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |