SCHEMBL11289092

SCHEMBL11289092

CCNCCNCCNCCNC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.56
MEN1 O00255 1/20 0.56
GLA P06280 1/20 0.56
KMT2A Q03164 1/20 0.56
CYP1A2 P05177 1/20 0.53
TSHR P16473 2/20 0.45
TP53 P04637 2/20 0.44
KDM1A O60341 5/20 0.42
SAT1 P21673 3/20 0.40
EPHX1 P07099 1/20 0.36
ALDH1A1 P00352 2/20 0.33
PRMT3 O60678 1/20 0.32
CARM1 Q86X55 1/20 0.32
PRMT6 Q96LA8 1/20 0.32
PRMT1 Q99873 1/20 0.32
PRMT8 Q9NR22 1/20 0.32
S1PR2 O95136 3/20 0.30
S1PR4 O95977 3/20 0.30
S1PR1 P21453 3/20 0.30
S1PR3 Q99500 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21003492 1.00 CYP2C19 (0.56) CYP2C19MEN1GLAKMT2ACYP1A2
SCHEMBL8343514 1.00 CYP2C19 (0.56) CYP2C19MEN1GLAKMT2ACYP1A2
SCHEMBL1788030 0.97
Bromide SCHEMBL7116645 0.93
Hydrochloric Acid SCHEMBL7115854 0.93
Iodide SCHEMBL7112955 0.93
SCHEMBL16948506 0.86 CARM1 (0.39) CYP2C19MEN1GLAKMT2ACYP1A2
SCHEMBL30612397 0.86 CYP2C19 (0.71) CYP2C19MEN1GLAKMT2ACYP1A2
SCHEMBL2893263 0.86 CYP2C19 (0.71) CYP2C19MEN1GLAKMT2ACYP1A2
SCHEMBL6131298 0.86 CARM1 (0.39) CYP2C19MEN1GLAKMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3188799-B1 METHODS FOR TREATING AGING AND SKIN DISORDERS USING NUCLEIC ACIDS TARGETING TYR OR MMP1 PHIO PHARM CORP (US) 2022-07-06 EP disclosed
US-11118178-B2 Reduced size self-delivering RNAI compounds PHIO PHARMACEUTICALS CORP. (US) 2021-09-14 US disclosed
WO-2019032619-A9 CHEMICALLY MODIFIED OLIGONUCLEOTIDES PHIO PHARMACEUTICALS CORP. (US) 2020-02-13 WO disclosed
EP-2550001-B1 RNA INTERFERENCE IN OCULAR INDICATIONS PHIO PHARM CORP (US) 2019-05-22 EP disclosed
WO-2019032619-A1 CHEMICALLY MODIFIED OLIGONUCLEOTIDES PHIO PHARMACEUTICALS CORP. (US) 2019-02-14 WO disclosed
US-20170067056-A1 RNA INTERFERENCE IN DERMAL AND FIBROTIC INDICATIONS RXI PHARMACEUTICALS CORPORATION (US) 2017-03-09 US disclosed
US-20170051290-A1 METHODS FOR TREATMENT OF DISORDERS IN THE FRONT OF THE EYE UTILIZING NUCLEIC ACID MOLECULES RXI PHARMACEUTICALS CORPORATION (US) 2017-02-23 US disclosed
US-20170051288-A1 METHODS FOR TREATING CANCER USING NUCLEIC ACIDS TARGETING MDM2 OR MYCN RXI PHARMACEUTICALS CORPORATION (US) 2017-02-23 US disclosed
WO-2017007813-A1 NUCLEIC ACID MOLECULES TARGETING SUPEROXIDE DISMUTASE 1 (SOD1) RXI PHARMACEUTICALS CORPORATION (US) 2017-01-12 WO disclosed
US-20160304875-A1 METHODS FOR TREATMENT OF WOUND HEALING UTILIZING CHEMICALLY MODIFIED OLIGONUCLEOTIDES RXI PHARMACEUTICALS CORPORATION (US) 2016-10-20 US disclosed
US-20160130578-A1 REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS PHIO PHARMACEUTICALS CORP. 2016-05-12 US disclosed
US-20160115482-A1 RNA INTERFERENCE IN OCULAR INDICATIONS PHIO PHARMACEUTICALS CORP. 2016-04-28 US disclosed
WO-2015168108-A2 METHODS FOR TREATING CANCER USING NUCLEIC TARGETING MDM2 OR MYCN RXI PHARMACEUTICALS CORPORATION (US) 2015-11-05 WO disclosed
WO-2015168605-A1 METHODS FOR TREATMENT OF DISORDERS IN THE FRONT OF THE EYE UTILIZING NUCLEIC ACID MOLECULES RXI PHARMACEUTICALS CORPORATION (US) 2015-11-05 WO disclosed
US-9095504-B2 RNA interference in ocular indications RXI PHARMACEUTICALS CORPORATION 2015-08-04 US disclosed
US-9080171-B2 Reduced size self-delivering RNAi compounds RXi Parmaceuticals Corporation (US) 2015-07-14 US disclosed
US-20140113950-A1 INTERFERENCE IN DERMAL AND FIBROTIC INDICATIONS RXI PHARMACEUTICALS CORPORATION (US) 2014-04-24 US disclosed
US-20130131142-A1 RNA INTERFERENCE IN OCULAR INDICATIONS PHIO PHARMACEUTICALS CORP. 2013-05-23 US disclosed
US-20130131141-A1 REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS PHIO PHARMACEUTICALS CORP. 2013-05-23 US disclosed
EP-0058505-A1 Preparation of esters containing an alpha-cyano group in the alcohol portion of the esters FMC Corporation (US) 1982-08-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11118178-B2 Reduced size self-delivering RNAI compounds SNRPE, SARNP, LDLR CYP2C19 4883/4885MEN1 4272/4885GLA 3959/4885
US-20160304875-A1 METHODS FOR TREATMENT OF WOUND HEALING UTILIZING CHEMICALLY MODIFIED OLIGONUCLEOTIDES FN1, RXFP1, MMP1 CYP2C19 4743/4885MEN1 4351/4885GLA 882/4885
US-20130131142-A1 RNA INTERFERENCE IN OCULAR INDICATIONS RXRA, RXRB, RXRG CYP2C19 4442/4885MEN1 4837/4885GLA 3411/4885
US-20170051290-A1 METHODS FOR TREATMENT OF DISORDERS IN THE FRONT OF THE EYE UTILIZING NUCLEIC ACID MOLECULES POLRMT, NSUN3, ELAVL1 CYP2C19 4881/4885MEN1 1278/4885GLA 1643/4885
US-20160115482-A1 RNA INTERFERENCE IN OCULAR INDICATIONS RXRA, RXRB, RXRG CYP2C19 4442/4885MEN1 4837/4885GLA 3411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.