Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | HPRT1 | P00492 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.35 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[B]Triphenylene SCHEMBL29628013 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| Benzo[B]Triphenylene SCHEMBL29374595 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| SCHEMBL5555424 | 0.82 | GPR84 (0.41) | ALDH1A1HSD17B10HPRT1CYP2A6TSHR | |
| SCHEMBL4855544 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| Benzo[B]Triphenylene SCHEMBL71635 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| Benzo[B]Triphenylene SCHEMBL17537048 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| SCHEMBL415471 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| SCHEMBL14877458 | 0.76 | ALDH1A1 (0.52) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| SCHEMBL711515 | 0.76 | ALDH1A1 (0.52) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 | |
| SCHEMBL55388 | 0.76 | ALDH1A1 (0.52) | ALDH1A1HSD17B10HIF1ACYP1B1HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283112-B1 | COMPOSITIONS COMPRISING PRFA*MUTANT LISTERIA AND METHODS OF USE THEREOF | ADURO BIOTECH (US) | 2016-10-12 | — | — | EP | disclosed |
| US-20110287055-A1 | COMPOSITIONS COMPRISING PRFA* MUTANT LISTERIA AND MEHTODS OF USE THEREOF | ADURO BIOTECH (US) | 2011-11-24 | — | — | US | disclosed |
| US-7927606-B2 | Free-living microbes are provided in which the nucleic acid has been modified so that the microbe is attenuated for proliferation and/or which comprise genetic mutations that attenuate the ability of the microbe to repair its nucleic acid. Methods using the modified microbes for the activation antigens | ADURO BIOTECH (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2283112-A1 | COMPOSITIONS COMPRISING PRFA*MUTANT LISTERIA AND METHODS OF USE THEREOF | Aduro Biotech (US) | 2011-02-16 | — | — | EP | disclosed |
| US-7833775-B2 | Modified free-living microbes, vaccine compositions and methods of use thereof | ADURO BIOTECH (US) | 2010-11-16 | — | — | US | disclosed |
| US-20100162416-A1 | Multi-stage stem cell carcinogenesis | STEMLIFELINE, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-7695725-B2 | Modified free-living microbes, vaccine compositions and methods of use thereof | ADURO BIOTECH (US) | 2010-04-13 | — | — | US | disclosed |
| WO-2010037134-A2 | MULTI-STAGE STEM CELL CARCINOGENESIS | STEMLIFELINE, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
| US-20100068230-A1 | MODIFIED FREE-LIVING MICROBES, VACCINE COMPOSITIONS AND METHODS OF USE THEREOF | CHINOOK THERAPEUTICS, INC. | 2010-03-18 | — | — | US | disclosed |
| WO-2009143085-A1 | COMPOSITIONS COMPRISING PRFA*MUTANT LISTERIA AND METHODS OF USE THEREOF | ANZA THERAPEUTICS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| EP-0804074-A1 | TREATING RED BLOOD CELL SOLUTIONS WITH ANTI-VIRAL AGENTS | Cerus Corporation (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0773716-A1 | TREATING RED BLOOD CELL SOLUTIONS WITH ANTI-VIRAL AGENTS | Cerus Corporation (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996039818-A1 | TREATING RED BLOOD CELL SOLUTIONS WITH ANTI-VIRAL AGENTS | CERUS CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5559250-A | 5-/N,N-BIS/2-CHLOROETHYL/AMINO/METHYL-8-METHOXYPSORALEN | STERITECH, INC. (US) | 1996-09-24 | — | — | US | disclosed |
| WO-1996014737-A1 | TREATING RED BLOOD CELL SOLUTIONS WITH ANTI-VIRAL AGENTS | CERUS CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |
| WO-1993010266-A1 | DEVICE AND METHOD FOR DETECTION OF COMPOUNDS WHICH INTERCALATE WITH NUCLEIC ACIDS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) | 1993-05-27 | — | — | WO | disclosed |
| US-4968602-A | DIAGNOSIS OF GENETIC DISORDERS | MOLECULAR DIAGNOSTICS, INC. (US) | 1990-11-06 | — | — | US | disclosed |
| US-4959309-A | Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays | MOLECULAR DIAGNOSTICS, INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0187332-B1 | PHOTOCHEMICAL METHOD OF LABELLING NUCLEIC ACIDS FOR DETECTION IN HYBRIDIZATION ASSAYS | MOLECULAR DIAGNOSTICS, INC. (US) | 1989-02-01 | — | — | EP | disclosed |
| US-4563417-A | MEDICAL DIAGNOSIS | MILES LABORATORIES, INC. (US) | 1986-01-07 | — | — | US | disclosed |