Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10406584 | 0.82 | ALDH1A1 (0.47) | MAPTHTTNPC1RAB9AALDH1A1 | |
| SCHEMBL9613866 | 0.82 | L3MBTL1 (0.35) | MAPTALDH1A1POLBHPGDKDM4E | |
| SCHEMBL8872909 | 0.76 | MAPT (0.48) | MAPTHTTNPC1RAB9AALDH1A1 | |
| SCHEMBL21337575 | 0.76 | MAPT (0.48) | MAPTHTTNPC1RAB9AALDH1A1 | |
| SCHEMBL225740 | 0.76 | NPC1 (0.50) | MAPTHTTNPC1RAB9AALDH1A1 | |
| SCHEMBL1758595 | 0.73 | RAPGEF4 (0.48) | MAPTHTTRAB9AALDH1A1GAA | |
| SCHEMBL4739123 | 0.73 | L3MBTL1 (0.50) | MAPTNPC1GAAPOLBHPGD | |
| SCHEMBL10406585 | 0.73 | RAPGEF4 (0.50) | HTTRAB9AALDH1A1GAAHPGD | |
| SCHEMBL6304704 | 0.71 | SIGMAR1 (0.36) | — | |
| SCHEMBL1268879 | 0.71 | ALDH1A1 (0.44) | MAPTHTTALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4352928-A | ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-10-05 | — | — | US | disclosed |
| EP-0022481-A1 | 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions | Mitsubishi Yuka Pharmaceutical Co., Ltd. (JP) | 1981-01-21 | — | — | EP | disclosed |