Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.73 |
| ▸ | RORC | P51449 | 1/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290507 | 0.89 | MAPT (0.60) | ABL1RORCRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9893009 | 0.86 | ABL1 (1.00) | ABL1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL11287330 | 0.85 | NPC1 (0.70) | ABL1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL13200859 | 0.84 | ELOVL1 (0.67) | RORCMAPTROCK2ROCK1MEN1 | |
| SCHEMBL7496737 | 0.83 | EGFR (0.74) | ABL1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL208697 | 0.82 | MEN1 (0.72) | SMN1; SMN2MAPTROCK1MEN1KMT2A | |
| SCHEMBL2093712 | 0.78 | ABL1 (0.70) | ABL1AOC3RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28759631 | 0.78 | ABL1 (0.70) | ABL1AOC3RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28199635 | 0.78 | RAB9A (0.72) | ABL1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL11279870 | 0.77 | LTA4H (0.71) | RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4348403-A | 2-Amino-4-(4-benzyloxyphenyl)thiazoles, and their use in hyperlipemia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-09-07 | — | — | US | claimed |
| EP-0027957-A1 | 2-Amino-4-(4-benzyloxyphenyl)thiazoles, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1981-05-06 | — | — | EP | claimed |
| US-4348403-A | 2-Amino-4-(4-benzyloxyphenyl)thiazoles, and their use in hyperlipemia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1982-09-07 | — | — | US | disclosed |
| EP-0027957-A1 | 2-Amino-4-(4-benzyloxyphenyl)thiazoles, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1981-05-06 | — | — | EP | disclosed |