Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.63 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | RORC | P51449 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | WNT3A | P56704 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290507 | 0.87 | MAPT (0.60) | APPROCK1RORCKMT2AMEN1 | |
| SCHEMBL208697 | 0.86 | MEN1 (0.72) | ROCK1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11290339 | 0.84 | ABL1 (0.73) | ROCK1RORCKMT2AMEN1MAPT | |
| SCHEMBL19380614 | 0.81 | ELOVL1 (1.00) | ELOVL1APPROCK1PRKACARORC | |
| SCHEMBL13200878 | 0.81 | RAB9A (0.63) | ELOVL1APPROCK1PRKACAKMT2A | |
| SCHEMBL3615467 | 0.81 | KMT2A (0.88) | ELOVL1ROCK1PRKACARORCKMT2A | |
| SCHEMBL13357345 | 0.81 | WNT3A (0.83) | ELOVL1ROCK1PRKACARORCKMT2A | |
| SCHEMBL11287330 | 0.78 | NPC1 (0.70) | KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL13357604 | 0.78 | ROCK1 (1.00) | ELOVL1APPROCK1PRKACAKMT2A | |
| SCHEMBL12303085 | 0.77 | WNT3A (0.90) | ELOVL1APPROCK1PRKACARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |