Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | LAP3 | P28838 | 3/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7327258 | 0.81 | ALDH1A1 (0.55) | ALDH1A1GAATDP1POLBL3MBTL1 | |
| SCHEMBL11177177 | 0.78 | TDP1 (0.54) | ALDH1A1GAATDP1POLBL3MBTL1 | |
| SCHEMBL11169560 | 0.77 | TDP1 (0.52) | ALDH1A1GAATDP1POLBL3MBTL1 | |
| SCHEMBL8928325 | 0.75 | LAP3 (0.53) | LAP3ANPEPACP3LMNATSHR | |
| SCHEMBL3444977 | 0.73 | ALDH1A1 (0.61) | ALDH1A1GAATDP1POLBL3MBTL1 | |
| SCHEMBL478614 | 0.73 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL4861809 | 0.73 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL1237351 | 0.73 | ALDH1A1 (0.61) | ALDH1A1GAATDP1POLBL3MBTL1 | |
| SCHEMBL392680 | 0.73 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 | |
| SCHEMBL30216480 | 0.73 | ALDH1A1 (1.00) | ALDH1A1GAAPOLBL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0058427-A2 | Substituted phosphonamides, a process for preparing the same and a pharmaceutical composition which is useful in the treatment of hypertension | MERCK & CO. INC. (US) | 1982-08-25 | — | — | EP | disclosed |