Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | ASF1A | Q9Y294 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | ESRRG | P62508 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15974230 | 1.00 | KDM4E (0.60) | KDM4EASF1APOLBGAAESRRG | |
| SCHEMBL24784482 | 1.00 | KDM4E (0.60) | KDM4EASF1APOLBGAAESRRG | |
| SCHEMBL21435733 | 0.87 | HDAC1 (0.59) | KDM4EPOLBRAB9ALMNA | |
| SCHEMBL21435735 | 0.87 | HDAC1 (0.59) | KDM4EPOLBRAB9ALMNA | |
| SCHEMBL12838364 | 0.86 | GAA (0.74) | KDM4EASF1APOLBGAAESRRG | |
| SCHEMBL11300020 | 0.86 | GAA (0.74) | KDM4EASF1APOLBGAAESRRG | |
| SCHEMBL27177901 | 0.83 | GAA (0.61) | KDM4EASF1APOLBGAAESRRG | |
| SCHEMBL10326230 | 0.83 | GAA (0.61) | KDM4EASF1APOLBGAAESRRG | |
| SCHEMBL3000250 | 0.83 | L3MBTL1 (0.57) | POLBGAAALDH1A1MAPTNPC1 | |
| SCHEMBL1520567 | 0.83 | ALDH1A1 (0.64) | KDM4EPOLBGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3461816-B1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-03-24 | — | — | EP | disclosed |
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | FIRMENICH INCORPORATED (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3461816-A1 | FIVE-MEMBERED HETEROCYLIC COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-2958897-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2019-01-09 | — | — | EP | disclosed |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-12-28 | — | — | US | disclosed |
| US-9840471-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| CN-105566311-A | Oxazole and isoxazole crac modulators | LUPIN LTD | 2016-05-11 | — | — | CN | disclosed |
| CN-103228636-B | Calcium modulators of oxazole and isoxazole calcium release activation | LUPIN LTD. (IN) | 2016-02-10 | — | — | CN | disclosed |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2015-12-31 | — | — | US | disclosed |
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |
| EP-2665771-A2 | A RUBBER COMPOSITION SUITABLE FOR USE AS A CAP PLY IN A TIRE | Bridgestone Americas Tire Operations, LLC (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012099955-A2 | A RUBBER COMPOSITION SUITABLE FOR USE AS A CAP PLY IN A TIRE | BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC (US) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10421727-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | KDM4E 4328/4885ASF1A 3984/4885POLB 4409/4885 |
| US-20150376136-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | KDM4E 4328/4885ASF1A 3984/4885POLB 4409/4885 |
| US-20170369447-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM7, TRPA1 | KDM4E 4328/4885ASF1A 3984/4885POLB 4409/4885 |
| US-11028052-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM7, TRPA1 | KDM4E 4328/4885ASF1A 3984/4885POLB 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.