Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.60 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.50 |
| ▸ | C5 | P01031 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | GPR3 | P46089 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517221 | 0.85 | KIF11 (0.58) | KIF11PDPK1KMT2AMEN1PTGS2 | |
| SCHEMBL498758 | 0.84 | PTGS2 (0.70) | KIF11PDPK1KMT2AMEN1PTGS2 | |
| SCHEMBL29760781 | 0.84 | PTGS2 (0.70) | KIF11PDPK1KMT2AMEN1PTGS2 | |
| SCHEMBL12286224 | 0.78 | KIF11 (0.66) | KIF11KMT2AMEN1PTGS2AHR | |
| SCHEMBL7516727 | 0.78 | KIF11 (0.57) | KIF11PDPK1KMT2AMEN1PTGS2 | |
| SCHEMBL27542917 | 0.76 | KMT2A (0.49) | PDPK1KMT2AMEN1POLBAHR | |
| Carbazole SCHEMBL8411559 | 0.75 | ALDH1A1 (0.74) | KIF11KMT2AMEN1POLBAHR | |
| SCHEMBL10892550 | 0.75 | KIF11 (1.00) | KIF11AHRMAPTALDH1A1KDM4E | |
| SCHEMBL11067278 | 0.74 | KMT2A (0.66) | KIF11KMT2AMEN1PTGS2AHR | |
| SCHEMBL8189543 | 0.74 | KIF11 (0.60) | KIF11KMT2AMEN1PTGS2ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008446-B1 | PROCESS FOR THE PREPARATION OF CARBAZOLES AND NOVEL CARBAZOLE DERIVATIVES UTILIZED THEREIN | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-22 | — | — | EP | disclosed |