Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.42 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11294282 | 0.83 | MTNR1A (0.64) | MTNR1AMTNR1BTAOK1TAOK3 | |
| SCHEMBL8885912 | 0.76 | CA1 (0.40) | MTNR1AMTNR1BTAOK1TAOK3 | |
| SCHEMBL6561215 | 0.76 | GRM7 (0.60) | MTNR1AMTNR1BMAPTTAOK1TAOK3 | |
| SCHEMBL9759525 | 0.74 | DRD2 (0.43) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL1965788 | 0.74 | MTNR1A (0.52) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL8887633 | 0.74 | HTR1D (0.57) | MTNR1AMTNR1BTAOK1TAOK3 | |
| SCHEMBL9758631 | 0.73 | MTNR1A (0.41) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| SCHEMBL9241335 | 0.72 | MTNR1A (0.68) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL9242722 | 0.72 | MTNR1A (0.67) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL9243601 | 0.72 | MTNR1A (0.67) | MTNR1AMTNR1BCYP1A2MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1981003491-A1 | THERAPEUTICALLY USEFUL TETRALIN DERIVATIVES | ASTRA LAEKEMEDEL AB (SE) | 1981-12-10 | — | — | WO | disclosed |
| EP-0041488-A1 | Therapeutically useful tetralin derivatives | Arvidsson, Folke Lars-Erik (SE) | 1981-12-09 | — | — | EP | disclosed |