Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 4/20 | 0.60 |
| ▸ | MME | P08473 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.45 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11294282 | 0.90 | MTNR1A (0.64) | GRM7MMEMTNR1AMTNR1BTAOK1 | |
| SCHEMBL6561214 | 0.84 | CA1 (0.56) | GRM7MMECA1CA2CA12 | |
| SCHEMBL14011280 | 0.80 | GRM7 (0.71) | GRM7MTNR1AMTNR1BHRH3MAPT | |
| SCHEMBL6560917 | 0.80 | GAA (0.54) | CA1CA2CA12CA7CA9 | |
| SCHEMBL25343056 | 0.78 | GRM7 (0.67) | GRM7MTNR1AMTNR1BHRH3MAPT | |
| SCHEMBL10421949 | 0.78 | GRM7 (0.67) | GRM7MTNR1AMTNR1BHRH3MAPT | |
| SCHEMBL10421951 | 0.78 | GRM7 (0.67) | GRM7MTNR1AMTNR1BHRH3MAPT | |
| SCHEMBL8887633 | 0.77 | HTR1D (0.57) | GRM7CA1CA2CA12CA7 | |
| SCHEMBL10447971 | 0.77 | GRM7 (0.57) | GRM7CA1CA2CA12CA7 | |
| SCHEMBL11298161 | 0.76 | MTNR1A (0.54) | MTNR1AMTNR1BMAPTTAOK1TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091946-B1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2004-03-17 | — | — | EP | disclosed |
| US-6291494-B1 | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use | ASTRAZENECA AB (SE) | 2001-09-18 | — | — | US | disclosed |
| EP-1091946-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTRÖM, Hakan Vilhelm (NL) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001680-A1 | NEW 2-AMINOTHIAZOL-FUSED 2-AMINOINDANS AND 2-AMINOTETRALINS AND THEIR USE | WIKSTROEM HAKAN VILHELM (NL) | 2000-01-13 | — | — | WO | disclosed |