Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.45 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11294282 | 0.84 | MTNR1A (0.64) | MTNR1AMTNR1BGRM7TAOK1TAOK3 | |
| SCHEMBL8885912 | 0.82 | CA1 (0.40) | HTR1DHTR1BMTNR1AMTNR1BCA1 | |
| SCHEMBL5121715 | 0.79 | HTR1D (0.60) | HTR1DHTR1BPSEN1PSEN2APH1B | |
| SCHEMBL5121719 | 0.79 | HTR1D (0.60) | HTR1DHTR1BPSEN1PSEN2APH1B | |
| SCHEMBL2819567 | 0.79 | HTR1D (0.60) | HTR1DHTR1BPSEN1PSEN2APH1B | |
| SCHEMBL8884861 | 0.78 | GAA (0.43) | HTR1DHTR1BMTNR1AMTNR1BCA1 | |
| SCHEMBL6561215 | 0.77 | GRM7 (0.60) | MTNR1AMTNR1BGRM7CA1CA2 | |
| SCHEMBL6932016 | 0.76 | MTNR1A (0.38) | MTNR1AMTNR1BCA1CA2CA12 | |
| SCHEMBL6561214 | 0.76 | CA1 (0.56) | GRM7CA1CA2CA12CA7 | |
| SCHEMBL11298161 | 0.74 | MTNR1A (0.54) | MTNR1AMTNR1BTAOK1TAOK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650427-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1997-07-22 | — | — | US | disclosed |
| US-5461061-A | Antidepressants | WIKSTROM HAKAN V (NL) | 1995-10-24 | — | — | US | disclosed |
| US-5288748-A | Antidepressants | THE UPJOHN COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |
| WO-1991011435-A2 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | THE UPJOHN COMPANY (US) | 1991-08-08 | — | — | WO | disclosed |