Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28457553 | 0.81 | CYP19A1 (0.38) | KDM4EHSD17B10GAAPOLBMAPK1 | |
| SCHEMBL11328645 | 0.76 | GAA (0.33) | GAA | |
| SCHEMBL28079301 | 0.76 | HPGD (0.44) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL27774577 | 0.72 | TP53 (0.50) | KDM4EALDH1A1HPGDRAB9APOLB | |
| SCHEMBL12373225 | 0.71 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL30391548 | 0.70 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL51589 | 0.70 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL10323651 | 0.69 | MGAM (0.65) | KDM4EALDH1A1RAB9AMGAMAMY1A | |
| Hydrochloric Acid SCHEMBL4717368 | 0.68 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10RAB9A | |
| SCHEMBL10893735 | 0.67 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |