SCHEMBL11299427

SCHEMBL11299427

CN(C)C(=O)OCCc1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.55
CHRNA4 P43681 3/20 0.55
CHRNB4 P30926 2/20 0.55
CHRNA3 P32297 2/20 0.55
HCAR2 Q8TDS4 1/20 0.53
TDP1 Q9NUW8 2/20 0.52
ESR1 P03372 1/20 0.51
ESR2 Q92731 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
ALDH1A1 P00352 1/20 0.50
TP53 P04637 1/20 0.50
GLA P06280 1/20 0.50
CYP3A4 P08684 1/20 0.50
HPGD P15428 1/20 0.50
TSHR P16473 1/20 0.50
MAPK1 P28482 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HIF1A Q16665 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11223525 0.88 LMNA (0.56) CHRNB2CHRNA4CHRNB4CHRNA3NPC1
SCHEMBL15651532 0.82 NPC1 (0.51) CHRNB2CHRNA4CHRNB4CHRNA3TDP1
SCHEMBL9536394 0.82 CHRNB2 (0.49) CHRNB2CHRNA4CHRNB4CHRNA3HCAR2
SCHEMBL30781857 0.82 CHRNB2 (0.52) CHRNB2CHRNA4CHRNB4CHRNA3HCAR2
Trimethylammonium SCHEMBL9482623 0.81 ALDH1A1 (0.58) HCAR2TDP1ESR1ESR2NPC1
SCHEMBL17434764 0.81 TDP1 (0.56) HCAR2TDP1ESR1ESR2NPC1
SCHEMBL30781926 0.81 ATM (0.46) CHRNB2CHRNA4CHRNB4CHRNA3HCAR2
Benzyl Dimethylcarbamate SCHEMBL5134244 0.81 ALDH1A1 (0.62) CHRNB2CHRNA4CHRNB4CHRNA3HCAR2
Benzyl Dimethylcarbamate SCHEMBL14031385 0.81 ALDH1A1 (0.62) CHRNB2CHRNA4CHRNB4CHRNA3HCAR2
Benzyl Dimethylcarbamate SCHEMBL20401678 0.81 ALDH1A1 (0.62) CHRNB2CHRNA4CHRNB4CHRNA3HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8222200-B2 Organic compounds GIVAUDAN SA (CH) 2012-07-17 US disclosed
US-8222200-B2 Organic compounds GIVAUDAN SA (CH) 2012-07-17 US disclosed
EP-1613587-B1 ORGANIC COMPOUNDS GIVAUDAN SA (CH) 2009-12-30 EP disclosed