SCHEMBL9536394

SCHEMBL9536394

CN(CCO)C(=O)OCCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.49
CHRNB4 P30926 2/20 0.49
CHRNA3 P32297 2/20 0.49
CHRNA4 P43681 2/20 0.49
HCAR2 Q8TDS4 1/20 0.46
ESR1 P03372 1/20 0.45
ESR2 Q92731 1/20 0.45
TDP1 Q9NUW8 2/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
ALDH1A1 P00352 1/20 0.44
TP53 P04637 1/20 0.44
GLA P06280 1/20 0.44
CYP3A4 P08684 1/20 0.44
HPGD P15428 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HIF1A Q16665 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30781857 0.88 CHRNB2 (0.52) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL553299 0.84 ALDH1A1 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL30781926 0.84 ATM (0.46) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL11299427 0.82 CHRNB2 (0.55) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL28761848 0.81 L3MBTL1 (0.48) HCAR2ESR1ESR2TDP1NPC1
SCHEMBL27655078 0.80 ALDH1A1 (0.49) CHRNB2CHRNB4CHRNA3CHRNA4HCAR2
SCHEMBL12665931 0.79 CHRNB2 (0.47) CHRNB2CHRNB4CHRNA3CHRNA4TDP1
SCHEMBL12311311 0.78 ALDH1A1 (0.45) CHRNB2CHRNB4CHRNA3CHRNA4L3MBTL1
SCHEMBL30720214 0.78 CHRNB2 (0.46) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL12311246 0.78 CHRNB2 (0.46) CHRNB2CHRNB4CHRNA3CHRNA4RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0555251-A1 THIAZOLIDINE DIONE DERIVATIVES BEECHAM GROUP plc (GB) 1993-08-18 EP disclosed
WO-1992007838-A1 THIAZOLIDINE DIONE DERIVATIVES BEECHAM GROUP PLC (GB) 1992-05-14 WO disclosed