Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11295039 | 0.86 | PSEN1 (0.40) | KMT2AGAASLC6A3TSHR | |
| SCHEMBL11301603 | 0.85 | HDAC6 (0.38) | MEN1KMT2AKDM4E | |
| SCHEMBL11296058 | 0.85 | MEN1 (0.47) | MAPTMEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL11296532 | 0.85 | SLC6A3 (0.40) | MAPK14MAPTMEN1KMT2AKDM4E | |
| SCHEMBL11296615 | 0.82 | FLT1 (0.38) | MAPK14MAPTMEN1KMT2ASLC6A3 | |
| SCHEMBL11296506 | 0.77 | ALOX15 (0.44) | KDM4EL3MBTL1TSHR | |
| SCHEMBL11301790 | 0.74 | HDAC6 (0.36) | MEN1KMT2AKDM4E | |
| SCHEMBL11299163 | 0.73 | HDAC6 (0.40) | MEN1KMT2AKDM4E | |
| SCHEMBL11301107 | 0.72 | TDP1 (0.36) | MAPTMEN1KMT2AGAAL3MBTL1 | |
| SCHEMBL11301119 | 0.71 | MAPT (0.40) | MAPTMEN1KMT2AKDM4EOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |