Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11296058 | 0.89 | MEN1 (0.47) | KMT2AGAASMN1; SMN2TSHR | |
| SCHEMBL11296532 | 0.89 | SLC6A3 (0.40) | SLC6A3KMT2AGAASMN1; SMN2KCNH2 | |
| SCHEMBL11296615 | 0.88 | FLT1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11299441 | 0.86 | MAPK14 (0.37) | SLC6A3KMT2AGAATSHR | |
| SCHEMBL11301393 | 0.80 | ALOX15 (0.56) | KMT2AGAASMN1; SMN2 | |
| SCHEMBL11296506 | 0.79 | ALOX15 (0.44) | TSHRHSD17B10 | |
| SCHEMBL11303328 | 0.76 | HDAC8 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11299083 | 0.74 | HDAC6 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11298752 | 0.74 | HDAC8 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11296595 | 0.73 | HDAC6 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |