Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11295039 | 0.89 | PSEN1 (0.40) | KMT2ATSHRSMN1; SMN2GAA | |
| SCHEMBL11296532 | 0.88 | SLC6A3 (0.40) | MEN1KMT2ATSHRMAPTRAB9A | |
| SCHEMBL11299441 | 0.85 | MAPK14 (0.37) | MEN1KMT2ATSHRMAPTL3MBTL1 | |
| SCHEMBL11296506 | 0.84 | ALOX15 (0.44) | TSHRRAB9AL3MBTL1ALDH1A1HTT | |
| SCHEMBL11301393 | 0.83 | ALOX15 (0.56) | MEN1KMT2AMAPTRAB9AOPRD1 | |
| SCHEMBL11301136 | 0.80 | ROCK2 (0.42) | MEN1KMT2ATSHRMAPTRAB9A | |
| SCHEMBL11301119 | 0.80 | MAPT (0.40) | MEN1KMT2ATSHRMAPTRAB9A | |
| SCHEMBL11296615 | 0.80 | FLT1 (0.38) | MEN1KMT2AMAPTRAB9ACASP3 | |
| SCHEMBL11297519 | 0.78 | HDAC6 (0.43) | RAB9AALDH1A1SMN1; SMN2HTTPOLB | |
| SCHEMBL11297424 | 0.77 | HDAC1 (0.43) | MAPTRAB9AOPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665706-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012098132-A1 | NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |