SCHEMBL11299749

SCHEMBL11299749

Cc1ccc(Cl)c(C)c1N(CC(=O)O)C(=O)CSC(=O)C(C)C

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.34
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
PKM P14618 1/20 0.32
ALDH1A1 P00352 2/20 0.31
MAPT P10636 2/20 0.31
ALOX15 P16050 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11290011 0.90 MLYCD (0.33)
SCHEMBL11292054 0.90 SMN1; SMN2 (0.32) SMN1; SMN2
SCHEMBL11284341 0.89 RAB9A (0.39) MEN1KMT2APKMALDH1A1MAPT
SCHEMBL11314993 0.88 SMN1; SMN2 (0.33) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL11290459 0.88 SMN1; SMN2 (0.35) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL11289145 0.87 SMN1; SMN2 (0.32) SMN1; SMN2MEN1KMT2APKM
SCHEMBL11349473 0.86 SMN1; SMN2 (0.34) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL11290056 0.85 MLYCD (0.30)
SCHEMBL11297292 0.84 SMN1; SMN2 (0.33) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL11299120 0.83 SMN1; SMN2 (0.32) SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0014167-B1 Aniline derivatives with antifungal activity and process for their preparation RHONE-POULENC AGROCHIMIE (FR) 1982-06-30 EP disclosed
EP-0014167-A1 Aniline derivatives with antifungal activity and process for their preparation RHONE-POULENC AGROCHIMIE (FR) 1980-08-06 EP disclosed