SCHEMBL11301495

SCHEMBL11301495

Nc1nc(O)c2nc(C(O)C(O)CO)cnc2n1

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.38
PIK3CG P48736 3/20 0.34
PIK3CA P42336 1/20 0.32
PIK3CB P42338 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
DHFR P00374 1/20 0.31
ADORA2A P29274 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4361085 0.82 HSD17B10 (0.48) HSD17B10PIK3CGPIK3CAPIK3CBHDAC6
SCHEMBL25899100 0.77 HSD17B10 (0.39) HSD17B10PIK3CGPIK3CAPIK3CBHDAC6
SCHEMBL24629319 0.74 PIK3CG (0.42) PIK3CGPIK3CAPIK3CBHDAC6DHFR
SCHEMBL9201051 0.74 HSD17B10 (0.38) HSD17B10PIK3CGPIK3CAPIK3CBHDAC6
SCHEMBL13314521 0.74 HSD17B10 (0.69) HSD17B10
SCHEMBL30287655 0.74 HSD17B10 (0.69) HSD17B10
SCHEMBL59520 0.74 HSD17B10 (0.69) HSD17B10
SCHEMBL59519 0.74 HSD17B10 (0.69) HSD17B10
SCHEMBL4542003 0.74 HSD17B10 (0.69) HSD17B10
SCHEMBL29776903 0.74 HSD17B10 (0.69) HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105228521-A The new diagnostic method of diagnosis depression and monitor treatment effect BRAINLABS B V 2016-01-06 CN claimed
CN-1795010-A Humanized antibodies to interferon alpha receptor-1 (ifnar-1) MEDAREX INC (US) 2006-06-28 CN claimed
JP-56099484-A None JP disclosed
CN-103620058-B Automated circulating tumor cell detection 西门子公司 2017-04-12 CN disclosed
CN-106461654-A Method for transferring beads 斯潘奇普诊断公司 2017-02-22 CN disclosed
CN-106461653-A Method of separating beads in a fluidic chip 斯潘奇普诊断公司 2017-02-22 CN disclosed
CN-104302408-B XTEN conjugate compositions and methods of making the same 阿穆尼克斯运营公司 2016-12-14 CN disclosed
CN-105722518-A Treatment of brain cancer with oncolytic adenovirus 德那翠丝有限公司 2016-06-29 CN disclosed
CN-105435223-A Methods of treating chronic inflammatory diseases using a GM-CSF antagonist KALOBIOS PHARMACEUTICALS INC 2016-03-30 CN disclosed
CN-105228521-A The new diagnostic method of diagnosis depression and monitor treatment effect BRAINLABS B V 2016-01-06 CN disclosed
CN-105007933-A Selective Nox1 inhibitor peptides and uses thereof UNIV BORDEAUX 2015-10-28 CN disclosed
CN-1177581-C Aqueous aerosol preparations containing biologically active macromolecules and method for producing the corresponding aerosols ���ָ��Ӣ��ķ�������Ϲ�˾ 2004-12-01 CN disclosed
CN-1457258-A Methods of treating viral diseases with IL-18 and IL-18 compositions SMITHKLINE BEECHAM CORP (US) 2003-11-19 CN disclosed
CN-1441677-A Combination of anti-cytokine antibodies or antagonists with anti-CD 20 for treatment of B cell lymphomas IDEC PHARMA CORP (US) 2003-09-10 CN disclosed
CN-1299285-A Recombinant human interferon beta-1A (IFN-beta-1A) formulation BIOGEN INC (US) 2001-06-13 CN disclosed
CN-1282255-A IFNAR2/1FN complex APPLIED RESEARCH SYSTEMS (NL) 2001-01-31 CN disclosed
CN-1265583-A Aqueous aerosol preparations containing biologically active macromolecules and method for producing the corresponding aerosols BOEHRINGER INGELHEIM PHARMA (DE) 2000-09-06 CN disclosed
CN-1245434-A Stable liquid interferon formulations BIOGEN INC (US) 2000-02-23 CN disclosed
CN-1216470-A Dehydroepiandrosterone combination therapy PRENDERGAST PATRICK T (IE) 1999-05-12 CN disclosed
JP-S5699484-A PTERIN DERIVATIVE AND DETERMINATION OF PTERINS DAIICHI RAJIO ISOTOPE KENKYUSHO:KK 1981-08-10 JP disclosed