Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27233210 | 0.81 | L3MBTL1 (0.41) | HDAC3RAB9AL3MBTL1FGFR1MEN1 | |
| SCHEMBL79979 | 0.77 | MEN1 (0.41) | KDM4EMAPTRAB9AL3MBTL1MEN1 | |
| SCHEMBL11594393 | 0.76 | IDO1 (0.65) | IDO1HDAC3EP300KAT2BKAT8 | |
| SCHEMBL25934912 | 0.76 | IDO1 (0.43) | IDO1HDAC3EP300KAT2BKAT8 | |
| SCHEMBL1057913 | 0.76 | IDO1 (0.52) | IDO1HDAC3EP300KAT2BKAT8 | |
| SCHEMBL10633413 | 0.74 | APP (0.34) | KDM4EMAPTNPSR1L3MBTL1MEN1 | |
| SCHEMBL2607720 | 0.74 | L3MBTL1 (0.50) | HDAC3KDM4EMAPTRAB9ANPSR1 | |
| SCHEMBL10351891 | 0.74 | MEN1 (0.48) | L3MBTL1MEN1KMT2AMAPK1 | |
| SCHEMBL647859 | 0.74 | PTGS2 (0.46) | IDO1HDAC3EP300KAT2BKAT8 | |
| SCHEMBL6138710 | 0.73 | L3MBTL1 (0.49) | HDAC3KDM4EMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4351848-A | 1-((1-Methylethyl)amino)-3-(((4-alkylthio)1-naphthalenyl)oxy)-2-propanol | DRUG SCIENCE FOUNDATION (US) | 1982-09-28 | — | — | US | disclosed |
| EP-0004300-B1 | 1-((1-METHYLETHYL)AMINO)-3-((4-ALKYLTHIO)-1-NAPHTHALENYL))OXY-2-PROPANOL, AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | Walle, Thomas (US) | 1981-01-07 | — | — | EP | disclosed |
| EP-0004300-A1 | 1-((1-Methylethyl)amino)-3-((4-alkylthio)-1-naphthalenyl))oxy-2-propanol, and pharmaceutical compositions containing it | Walle, Thomas (US) | 1979-10-03 | — | — | EP | disclosed |