SCHEMBL1130441

SCHEMBL1130441

C[SiH](C)[Hf](F)(F)(C1C=Cc2ccccc21)C1C=Cc2ccccc21

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.33
HTR2A P28223 2/20 0.32
SIGMAR1 Q99720 2/20 0.31
BRD4 O60885 1/20 0.30
CCL2 P13500 1/20 0.30
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
CHRM2 P08172 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
CHRM1 P11229 1/20 0.30
DRD2 P14416 1/20 0.30
ADRA2B P18089 1/20 0.30
ADRA2C P18825 1/20 0.30
NFKB1 P19838 1/20 0.30
CHRM3 P20309 1/20 0.30
SLC6A2 P23975 1/20 0.30
HTR2C P28335 1/20 0.30
ADRA1A P35348 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL814607 0.80 HTR2A (0.33) HTR6HTR2ASIGMAR1BRD4CCL2
SCHEMBL3384862 0.79 HTR2A (0.35) HTR6HTR2ASIGMAR1BRD4CCL2
SCHEMBL1130631 0.79 HTR6 (0.31) HTR6HTR2A
SCHEMBL216950 0.79 HTR6 (0.33) HTR6HTR2ASIGMAR1BRD4CCL2
SCHEMBL7629863 0.76 SIGMAR1 (0.32) HTR6HTR2ASIGMAR1
SCHEMBL6059230 0.76 HTR2A (0.35) HTR6HTR2A
SCHEMBL1131042 0.75 HTR6 (0.33) HTR6HTR2ASIGMAR1BRD4CCL2
SCHEMBL3382399 0.73 HTR6 (0.33) HTR6HTR2ASIGMAR1
SCHEMBL7636989 0.72 SIGMAR1 (0.38) HTR6HTR2ASIGMAR1
SCHEMBL3380486 0.72 HTR2A (0.35) HTR6HTR2ASIGMAR1BRD4CCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673401-B1 POLYMERIZATION PROCESS AND CONTROL OF POLYMER COMPOSITION PROPERTIES UNIVATION TECH LLC (US) 2015-10-21 EP disclosed
EP-1546212-B1 BIMODAL POLYOLEFIN PRODUCTION PROCESS AND FILMS THEREFROM UNIVATION TECH LLC (US) 2011-02-16 EP disclosed
EP-1673400-A4 POLYMERIZATION PROCESS AND CONTROL OF POLYMER COMPOSITION PROPERTIES UNIVATION TECH LLC (US) 2007-07-11 EP disclosed
EP-1673401-A4 POLYMERIZATION PROCESS AND CONTROL OF POLYMER COMPOSITION PROPERTIES UNIVATION TECH LLC (US) 2007-07-11 EP disclosed
US-7238756-B2 Polymerization process and control of polymer composition properties UNIVATION TECHNOLOGIES, LLC (US) 2007-07-03 US disclosed
EP-1551553-A4 PROCESS FOR PRODUCING FLUORINATED CATALYSTS UNIVATION TECH LLC (US) 2007-05-09 EP disclosed
EP-1546212-A4 BIMODAL POLYOLEFIN PRODUCTION PROCESS AND FILMS THEREFROM UNIVATION TECH LLC (US) 2006-07-05 EP disclosed
EP-1673401-A1 POLYMERIZATION PROCESS AND CONTROL OF POLYMER COMPOSITION PROPERTIES Univation Technologies, LLC (US) 2006-06-28 EP disclosed
EP-1673400-A1 POLYMERIZATION PROCESS AND CONTROL OF POLYMER COMPOSITION PROPERTIES Univation Technologies, LLC (US) 2006-06-28 EP disclosed
EP-1560857-A4 SYNTHESIS OF POLYMERIZATION CATALYST COMPONENTS UNIVATION TECH LLC (US) 2006-04-19 EP disclosed
US-6828395-B1 Polymerization process and control of polymer composition properties UNIVATION TECHNOLOGIES, LLC 2004-12-07 US disclosed
US-20040236045-A1 SYNTHESIS OF POLYMERIZATION CATALYST COMPONENTS MATSUNAGA PHILLIP T (US) 2004-11-25 US disclosed
WO-2004044010-A2 SYNTHESIS OF POLYMERIZATION CATALYST COMPONENTS UNIVATION TECHNOLOGIES, LLC (US) 2004-05-27 WO disclosed
US-20040092387-A1 Synthesis of polymerization catalyst components UNIVATION TECHNOLOGIES, LLC 2004-05-13 US disclosed
WO-2004022230-A1 PROCESS FOR PRODUCING FLUORINATED CATALYSTS UNIVATION TECHNOLOGIES, LLC (US) 2004-03-18 WO disclosed
WO-2004022607-A1 BIMODAL POLYOLEFIN PRODUCTION PROCESS AND FILMS THEREFROM UNIVATION TECHNOLOGIES, LLC (US) 2004-03-18 WO disclosed
US-20040043893-A1 Process for producing fluorinated catalysts UNIVATION TECHNOLOGIES, LLC 2004-03-04 US disclosed
US-20040044154-A1 Bimodal polyolefin production process and films therefrom UNIVATION TECHNOLOGIES, LLC 2004-03-04 US disclosed
US-20020143125-A1 Catalyst component and catalyst system having a high polymerization activity for preparing polymers KAMINSKY WALTER (DE) 2002-10-03 US disclosed
US-6303718-B1 PARTICULARLY A CATALYST SYSTEM CONSISTING OF METALLOCENE FLUORIDES AND ALUMINUM ALKYLS BAYER AKTIENGESELLSCHAFT (DE) 2001-10-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040043893-A1 Process for producing fluorinated catalysts FLI1, AFF1, INF2 HTR6 3619/4885HTR2A 3132/4885SIGMAR1 1013/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.