2,6-Dimethoxyquinone

2,6-Dimethoxyquinone

SCHEMBL11304693

COC1=CC(=O)C=C(OC)C1=O.[N-]=[N+]=N.[N-]=[N+]=[N-]

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HKDC1 Q2TB90 2/20 0.71
KDM4E B2RXH2 1/20 0.71
MEN1 O00255 1/20 0.71
USP2 O75604 1/20 0.71
TP53 P04637 1/20 0.71
CYP3A4 P08684 1/20 0.71
MAPT P10636 1/20 0.71
MAPK1 P28482 1/20 0.71
KMT2A Q03164 1/20 0.71
SMN1; SMN2 Q16637 1/20 0.71
ALOX5 P09917 7/20 0.53
PTGS2 P35354 6/20 0.53
TYR P14679 1/20 0.44
ERBB2 P04626 1/20 0.43
GLS2 Q9UI32 3/20 0.42
TEK Q02763 2/20 0.42
CDC25A P30304 2/20 0.40
CDC25B P30305 2/20 0.40
CDC25C P30307 1/20 0.40
IDO1 P14902 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2,6-Dimethoxyquinone SCHEMBL570683 0.84 HKDC1 (1.00) HKDC1KDM4EMEN1USP2TP53
2,6-Dimethoxyquinone SCHEMBL1706801 0.72 KDM4E (0.74) HKDC1KDM4EMEN1USP2TP53
SCHEMBL11303185 0.71 PTGS1 (0.34) HKDC1KDM4EMEN1USP2TP53
SCHEMBL684719 0.71 MAPT (0.73) HKDC1KDM4EMEN1USP2TP53
SCHEMBL7115894 0.70 ALOX5 (1.00) HKDC1KDM4EMEN1USP2TP53
SCHEMBL9364524 0.70 MAPT (0.70) HKDC1KDM4EMEN1USP2TP53
SCHEMBL21729822 0.70 HKDC1 (0.70) HKDC1KDM4EMEN1USP2TP53
SCHEMBL197028 0.69 HKDC1 (0.70) HKDC1KDM4EMEN1USP2TP53
SCHEMBL11300666 0.67 ALOX5 (0.43) ALOX5PTGS2
SCHEMBL10412600 0.67 ERBB2 (0.54) HKDC1KDM4EMEN1USP2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4280819-A FUEL ADDITIVES ALSO FOR JET FUELS GULF RESEARCH & DEVELOPMENT COMPANY (US) 1981-07-28 US disclosed