Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.53 |
| ▸ | AR | P10275 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11437726 | 0.92 | PGR (0.56) | PGRARADRA1AABCB11CYP3A4 | |
| SCHEMBL7596820 | 0.84 | PGR (0.61) | PGRARADRA1AABCB11CYP3A4 | |
| SCHEMBL11122100 | 0.81 | PGR (0.69) | PGRARADRA1AADORA3CHRM1 | |
| SCHEMBL11122098 | 0.81 | PGR (0.69) | PGRARADRA1AADORA3CHRM1 | |
| SCHEMBL11292006 | 0.81 | NR3C1 (0.67) | PGRARCHRM1ABCB11CYP3A4 | |
| SCHEMBL11126100 | 0.81 | PGR (0.69) | PGRARADRA1AADORA3CHRM1 | |
| SCHEMBL11421774 | 0.80 | PGR (0.80) | PGRARADRA1AABCB11CYP3A4 | |
| SCHEMBL11421776 | 0.80 | PGR (0.80) | PGRARADRA1AABCB11CYP3A4 | |
| SCHEMBL6859039 | 0.80 | CYP3A4 (0.61) | PGRARADRA1AABCB11CYP3A4 | |
| SCHEMBL6859043 | 0.80 | CYP3A4 (0.61) | PGRARADRA1AABCB11CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000742-B1 | CORTICOIDS-17-ALKYLCARBONATES, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-12 | — | — | EP | disclosed |
| EP-0000742-A1 | Corticoids-17-alkylcarbonates, process for their preparation and preparations containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-02-21 | — | — | EP | disclosed |