Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 8/20 | 0.61 |
| ▸ | CASP7 | P55210 | 2/20 | 0.55 |
| ▸ | NSD2 | O96028 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | TDO2 | P48775 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 3/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22830404 | 0.81 | GSR (0.52) | GSRCASP7NSD2IDO1CRHBP | |
| SCHEMBL1122732 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL1963617 | 0.75 | CFTR (0.68) | KDM4EALDH1A1HPGDGAACYP3A4 | |
| SCHEMBL1520226 | 0.74 | KMT2A (0.62) | ALDH1A1MAPTTP53HTTRAB9A | |
| SCHEMBL27154650 | 0.72 | KDM4E (0.61) | KDM4EALDH1A1HPGDGAACYP1A2 | |
| SCHEMBL5547053 | 0.72 | KDM4E (0.49) | CASP7KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL6387107 | 0.71 | HPGD (0.66) | KDM4EALDH1A1HPGDGAAMAPT | |
| SCHEMBL29603876 | 0.71 | NSD2 (1.00) | GSRCASP7NSD2IDO1CRHBP | |
| SCHEMBL5717623 | 0.70 | ALDH1A1 (0.67) | CASP7KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL2181905 | 0.69 | RAF1 (0.77) | CASP7KDM4EALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0030550-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY, Daniel (US) | 1981-06-24 | — | — | EP | claimed |
| WO-1980002799-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY D | 1980-12-24 | — | — | WO | claimed |
| EP-0030550-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY, Daniel (US) | 1981-06-24 | — | — | EP | disclosed |
| WO-1980002799-A1 | ANTIHYPERTENSIVE AGENTS AND THEIR USE IN TREATMENT OF HYPERTENSION | TRACHEWSKY D | 1980-12-24 | — | — | WO | disclosed |