Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.47 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | MPC2 | O95563 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177323 | 0.90 | PTPN1 (0.45) | PPARGMPC2CYP2C8CYP2C9MEN1 | |
| SCHEMBL8309388 | 0.90 | PPARG (0.44) | PPARGMPC2CYP2C8CYP2C9MEN1 | |
| SCHEMBL8857154 | 0.88 | PPARG (0.43) | PPARGMPC2CYP2C8CYP2C9MEN1 | |
| SCHEMBL8304179 | 0.83 | MCL1 (0.41) | PPARGMEN1KMT2APOLBMCL1 | |
| SCHEMBL27516237 | 0.80 | MAPT (0.51) | PPARGCYP2C9MEN1KMT2APOLB | |
| SCHEMBL8405115 | 0.79 | MTNR1A (0.38) | PPARGPTPN1 | |
| SCHEMBL8405118 | 0.79 | MTNR1A (0.38) | PPARGPTPN1 | |
| SCHEMBL8306634 | 0.77 | CTRB1 (0.41) | MEN1KMT2A | |
| SCHEMBL8563228 | 0.76 | PPARG (0.39) | PPARGCYP2C9MCL1MAPTKDM4E | |
| SCHEMBL8305019 | 0.76 | RECQL (0.42) | PPARGSMN1; SMN2MAPTKDM4EFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753298-B2 | Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis | SANKYO CO (JP) | 2011-02-16 | — | — | EP | disclosed |
| EP-0753298-B1 | Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis | SANKYO CO (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-6159997-A | Treatment of arteriosclerosis and xanthoma | SANKYO COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5798375-A | ADMINISTERING TO THE PATIENT PREVASTATIN A HYDROXY-3-METHYL-GLUTARYL/3-/ COENZYME A REDUCTASE INHIBITOR AND A INSULIN SENSITIZER TROGLITAZONE | SANKYO COMPANY, LIMITED (JP) | 1998-08-25 | — | — | US | disclosed |
| EP-0753298-A1 | Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis | SANKYO COMPANY LIMITED (JP) | 1997-01-15 | — | — | EP | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |